The latest big change (from a goldmaking perspective) is the news that you will that players will still be able to attain> Insane in the Membrane and "The Insane" title in World of Warcraft: Cataclysm
From what I have seen, those seeking insanity have providing us with cheap darkmoon cards, cheap runecloth, the occaisional cheap recipee. The have also propped up the herb market (for those darkmoon cards), pushed up the prices on librams and pristine diamonds.
The biggest change to the criteria to be delcared insane is that Exalted reputation with Shen'dralar will no longer be required.
However For those who already earned Exalted reputation with this faction ... In a future patch, we'll be adding in a separate Feat of Strength to recognize your deep love of Dire Maul..
By definition, anyone seeking insanity is a completionist. Blizzard has just told them that they don't need to spread themselves out to get all the achivements now, they only have to worry about Dire Maul to have that extra achievement. Serious contenders are likely to already know about this change. Those I know who want to be insane also want to have Exalted reps, and one is about to become unobtainable.
WoWwiki lists the requirements of the Shen'dralar, including the Pristine Black Diamonds and the librams.
It is my expectation that instead of madly panicing over getting all the achievements will now concentrate on Shen'dralar, including some that had previously thought they had left their run too late.
I expect a small drop in price for Librams and Pristine Black Diamonds, but one that is likely to have occured by the time you read this post. If you see either of these being panic sold, I would flip them.